ABOUT
SLIDE-VIP WebApp is a web-tool to explore the synthetic lethality relationship between a pair of genes using three different data sources: DepMap (cell line knock-out screens), TCGA (cancer patients gene expression and survival data) and GDSC/PRISM (drug screen) data. The user can view results and visualizations of 7 different SL tests for over 220 thousand potential SL gene pairs. Genes A come from DDR, chromatin remodeling and cell cycle pathways and are often mutated in cancer, while genes B - their potential SL partners, come from the same set of pathways or are targets of drugs in the advanced stage of development.
PUBLICATION
Synthetic lethality prediction in DNA damage repair, chromatin remodeling and the cell cycle using multi-omics data from cell lines and patients. Magda Markowska, Magdalena A. Budzinska, Anna Coenen-Stass, Senbai Kang, Ewa Kizling, Krzysztof Kolmus, Krzysztof Koras, Eike Staub, Ewa Szczurek. Scientific Reports.